The meandering pulmonary vein (MPV) is a rare congenital anomaly characterized by an additional pulmonary vein following an atypical course, with fewer than 50 cases reported. In this study, an MPV was identified during cadaveric dissection of a donor whose cause of death included COPD, pneumonia, and general decline. This case describes the MPV course, dimensions, and associated cardiac wall thickness, thereby contributing to the limited anatomical and clinical data on MPV. A formalin-fixed cadaver was obtained through the Colorado Anatomical Board’s Gift Program. Using Rocky Vista University’s dissection guide, students identified an anomalous pulmonary vein draining into the left atrium, consistent with MPV. Calipers were used to measure the MPV diameter, the thickness of the right and left ventricular walls, and the interventricular septum to assess for hypertrophy. Images documented both external and internal heart anatomy, including mapping of the MPV with a probe. A literature review on pulmonary venous anomalies and associated pathologies supplemented the findings. The MPV diameter measured 10.97” mm. The right ventricular wall measured 4.56” mm, the left ventricular wall 7.61” mm, and the interventricular septum 11.75” mm, indicating mild hypertrophy. Previous MPV cases describe presentations such as hemoptysis, mimicking scimitar syndrome, and associations with atrial fibrillation. Pulmonary venous anomalies may contribute to pulmonary venous hypertension and vein stenosis, leading to compensatory cardiac hypertrophy. The ventricular and septal thickening observed in this case aligns with these secondary changes. Given the rarity of MPV, this report adds valuable anatomical and clinical insight to the existing literature.
