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Streptococcus pyogenes (‘Group A strep’ or GAS), most commonly known as the causative agent for streptococcal pharyngitis or “strep throat,” is often transmitted through respiratory droplets or contact with contaminated surfaces. A much less documented and known specific mode of transmission, however, is via oro-genital exposure.

This case report describes a 23-year-old male with no significant past medical history, who presented with dysuria and suprapubic pain three days following oral-penile intercourse with his partner. Routine urine culture revealed that the patient was infected with Group A Streptococcus. The patient’s symptoms were resolved following treatment of a 10-day course of amoxicillin + clavulanate.

The case underscores the importance of considering non-traditional transmission routes for GAS, particularly in patients presenting with genitourinary complaints following sexual activity. If left untreated, GAS can progress to more severe complications, including Rheumatic Fever and Glomerulonephritis. Increased awareness among healthcare providers and the public about the potential for GAS to act as an STI could lead to better diagnosis and management, ultimately reducing the incidence of such infections.

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