Due to population aging, the number of new cases of Alzheimer's disease is expected to rise
dramatically in the coming years. Despite significant efforts in research and drug development,
finding effective treatments that can substantially alter the clinical course of Alzheimer's disease
(AD) remains a challenge. Alzheimer's disease has a complex molecular pathology that is
characterized by the presence of β-amyloid plaques and tau tangles in the brain, leading to
cognitive decline. The complex and multifaceted nature of the disease has made it difficult to
identify therapeutic targets that lead to meaningful improvements in patients. Current research has
demonstrated potential connections between these molecular mechanisms and caspases (apoptotic
pathway). This literature review examines the current research on caspases as a potential
therapeutic target in the treatment of AD and proposes potential mechanisms of action.
