Gliomas are the most common primary brain tumors in adults, with recurrence rates varying by tumor grade and
initial treatment. Reoperation is a key strategy for managing recurrence, yet its impact on health-related quality of
life (HRQoL) remains unclear. While existing literature highlights HRQoL and neurocognitive outcomes after pri-
mary treatment, little is known about these factors post-reoperation. This systematic review synthesizes available
evidence on HRQoL outcomes following glioma reoperation to guide clinical decision-making.
A systematic review was conducted using keyword search strings in PubMed and Google Scholar. Of 1,336 retrieved articles, 76 duplicates were removed, and 42 papers were sought for full-text retrieval. Studies were included if they used validated HRQoL tools such as the Karnofsky Performance Status (KPS), FACT-G, SF-36, and EQ-5D-L. Preliminary analysis of ten studies (total n = 1,518; reoperation group n = 602) suggests that KPS is the most commonly used functional assessment tool, while EQ-5D-L and FACT-G were utilized in select stud- ies. As full-text screening continues, additional patterns in HRQoL trends may emerge.
Initial findings indicate that 50% of studies report functional improvements, 37.5% note stability, and 37.5% observe declines in HRQoL post-reoperation. Higher preoperative functional status appears linked to better post- operative outcomes. While reoperation may help maintain or improve HRQoL in well-selected patients, ongoing analysis will further clarify these trends. Standardized prospective studies are needed to refine patient selection criteria and better define the long-term impact of reoperation on HRQoL.
A systematic review was conducted using keyword search strings in PubMed and Google Scholar. Of 1,336 retrieved articles, 76 duplicates were removed, and 42 papers were sought for full-text retrieval. Studies were included if they used validated HRQoL tools such as the Karnofsky Performance Status (KPS), FACT-G, SF-36, and EQ-5D-L. Preliminary analysis of ten studies (total n = 1,518; reoperation group n = 602) suggests that KPS is the most commonly used functional assessment tool, while EQ-5D-L and FACT-G were utilized in select stud- ies. As full-text screening continues, additional patterns in HRQoL trends may emerge.
Initial findings indicate that 50% of studies report functional improvements, 37.5% note stability, and 37.5% observe declines in HRQoL post-reoperation. Higher preoperative functional status appears linked to better post- operative outcomes. While reoperation may help maintain or improve HRQoL in well-selected patients, ongoing analysis will further clarify these trends. Standardized prospective studies are needed to refine patient selection criteria and better define the long-term impact of reoperation on HRQoL.