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Abstract
Vitiligo is a chronic skin disorder characterized by hypopigmented patches on various parts of the body. This study explores the spontaneous re-pigmentation of vitiligo in a white female from the age of 10 to 22. At age 10, the patient developed a hypopigmented patch on her right hip that rapidly spread to other areas of her body. By age 11, she was diagnosed with nonsegmental vitiligo and began a treatment regimen that included UVB light therapy, topical clobetasol propionate 0.05% ointment, tacrolimus 0.1% ointment, and compounded oral droplets of 1 mg B12 and 5mg folate. Despite these interventions, the response was limited, and treatment was discontinued at age 13. Following the onset of menarche at age 14, the patient experienced progressive re-pigmentation, which became noticeable at age 15 and led to 90% re-pigmentation by ages 18 to 22. This study investigates the potential influence of hormonal changes on vitiligo remission, aiming to address a knowledge gap. Exploring the impact of hormonal factors on melanogenesis and immune response mechanisms offers an avenue for developing innovative therapeutic strategies and improving treatment outcomes.